Carolina Panthers at Tampa Bay Buccaneers, Sunday 2:30PM, Sky Sports

Tampa Bay and Carolina face off for the second time this season in this Week 6 game. Tampa Bay are the nominated home team but this NFC South match-up takes place in London, in the Tottenham Hotspur Stadium. The Week 2 game between these franchises ended in a surprise 20-14 win for the Bucs and they now sit with a 2-3 record.

The Panthers opened the season with two home losses – including the Bucs – and their star quarterback hasn’t played since, missing out through injury. In his place backup QB Kyle Allen has stepped up to the mark. The undrafted free agent has thrown 5 touchdowns and 0 interceptions in his three winning regular season games to date. He has been helped by MVP candidate Christian McCaffrey who is doing more than his fair share in the receiving and rushing stakes.

McCaffrey has been other worldly this season, his only blip coming in that Week 2 loss to the Bucs. He is averaging over 200 yards of offense in his last three games. The Bucs rush defense is 3rd best in the league but they will struggle to restrict McCaffrey to 37 yards like they did in their first meeting.

The Panthers can stretch their winning streak to four this weekend.

BET: Carolina Panthers (-2)  – 25/27 with GiveMeBet

San Francisco 49ers at Los Angeles Rams, Sunday 9:05PM, Sky Sports

The 49ers have started 4-0 for the first time since 1990. On that occasion, they finished the season with a regular season record of 14-2 and a fourth Vince Lombardi Trophy to add to their collection. Joe Montana and Jerry Rice were the key duo back in those days, leading the 49ers to five Super Bowl victories in 13 seasons.

Jimmy Garoppolo and Deebo Samuel may not be as feared by defensive coordinators as that Hall of Fame pairing but they have made a good start to the 2019 season nonetheless. They made a statement on Monday night, beating the Cleveland Browns 31-3. This will be a different test altogether though. They have a combined 2-10 record against divisional rivals in the last two seasons and NFC champions Los Angeles Rams have more than enough firepower to give the 49ers their first loss of the season.

In this fixture last year the Rams beat the 49ers 39-10 with Todd Gurley running in with two TDs. It will be a lot tighter this year and the line of 3.5 looks appealing for the 49ers.

BET: San Francisco 49ers (+3.5) – 50/57 with GiveMeBet

Pittsburgh Steelers at Los Angeles Chargers, Monday 1:20AM, Sky Sports

The Los Angeles Chargers are early 6.5 points favourites for this Week 6 game. The Steelers’ backup QB Mason Rudolph will almost certainly miss out after leaving the field last Sunday against the Ravens with concussion. His replacement that day, Devlin Hodges, is in line for his first NFL start on Sunday. The Samford Graduate threw seven completions from nine attempts on Sunday on his way to an OT loss to the Ravens.

That performance was admirable from Hodges but playing the full four quarters of an NFL game is a different proposition. A win for the Chargers is crucial to get their season back on track and Melvin Gordon and Austin Ekeler will be hoping to get more involved this week.

BET: Los Angeles Chargers to win – 1/3 with GiveMeBet

*A treble on those three selections comes in around 5/1.

Week 6 Schedule & Betting Lines

All lines correct at time of writing. All times given are UK.

New York Giants (+16.5) @ New England Patriots, Friday 1:20AM

Philadelphia Eagles (+3) @ Minnesota Vikings, Sunday 6PM

Cincinnati Bengals (+11.5) @ Baltimore Ravens, Sunday 6PM

New Orleans Saints (+1.5) @ Jacksonville Jaguars, Sunday 6PM

Washington Redskins (-3.5) @ Miami Dolphins, Sunday 6PM

Houston Texans (+4.5) @ Kansas City Chiefs, Sunday 6PM

Seattle Seahawks (-2) @ Cleveland Browns, Sunday 6PM

Atlanta Falcons (-2.5) @ Arizona Cardinals, Sunday 9:05PM

Dallas Cowboys (-7) @ New York Jets, Sunday 9:25PM

Tennessee Titans (+2) @ Denver Broncos, Sunday 9:25PM

Detroit Lions (+4) @ Green Bay Packers, Tuesday 1:20PM

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